3 edition of Voltage-gated ion channels as drug targets found in the catalog.
Voltage-gated ion channels as drug targets
Includes bibliographical references and index.
|Statement||edited by David J. Triggle ... [et al.].|
|Series||Methods and principles in medical chemistry -- v. 29.|
|LC Classifications||QH603.I54 V65 2006, QH603.I54 V65 2006|
|The Physical Object|
|Pagination||xii, 479 p. :|
|Number of Pages||479|
|LC Control Number||2006296406|
Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. Table of Contents 1. Introduction—On Ion Channels 2. The Voltage-gated Ion Channel Superfamily. 3. State-dependent Drug Interactions with Ion Channels . Anesthetics (voltage-gated sodium channel) 2. Anti-hypertensives calcium channel blockers (voltage-gated calcium channels) 3. Nicotine (nicotnic Acetylcholine receptor) 4 Muscle relaxants (nicotnic Acetylcholine receptor) 5. Anti-anxiety drugs: e.g. Valium (GABA receptor) • Anti-epileptic drugs (GABA receptor).
(). Voltage gated sodium channels as drug discovery targets. Channels: Vol. 9, Special issue on Ion Channel Pharmacology and Drug Development, pp. Study 19 Chapter 3 Ion Channels as Targets of Psychopharmacological Drug Action flashcards from maria D. on StudyBlue. Chapter 3 Ion Channels as Targets of Psychopharmacological Drug Action - Nur with Frye at Drexel University College of Nursing - StudyBlue.
Ion channels remain an undeniably valuable type of drug-discovery target. However in the past years, researchers’ attempts to expand the number of validated ion-channel drug targets and create new drugs against these have, for the most part, fallen flat. There is debate as to why this has occurred. Important drug targets acting on Potassium channels - Duration: eGPAT views. Ion channels (voltage gated, ligand gated, stress activated ion channel) - Duration:
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David J. Triggle is a Professor for Pharmacy at the State University of New York at Buffalo, USA, where he is investigating drug-receptor interactions and has specialized in ion channel pharmacology. He is the author of several books, has contributed around papers, chapters and reviews, and has presented over 1, lectures worldwide.
Voltage-Gated Ion Channels as Drug Targets [David J. Triggle, Murali Gopalakrishnan, David Rampe, Wei Zheng, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers] on *FREE* shipping on qualifying offers.
Edited by the most prominent person in the field and top researchers Voltage-gated ion channels as drug targets book US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a. Content: Introduction: on ion channels / Murali Gopalakrishnan, David Rampe, David Triggle, Wei Zheng -- The voltage-gated ion channel superfamily / William A.
Catterall -- State-dependent drug interactions with ion channels / Stefan I. McDonough, Bruce P. Bean -- Assay technologies: techniques available for quantifying drug-channel interactions / Derek Leishman, Gareth Waldron -- Overview. Voltage-gated ion channels as drug targets.
Publication date Topics Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion cha Includes bibliographical references and index Introduction: on ion channels / Murali Gopalakrishnan, David Rampe, David Triggle, Wei Zheng.
Buy Voltage-Gated Ion Channels as Drug Targets: 29 (Methods and Principles in Medicinal Chemistry) by David J.
Triggle, Murali Gopalakrishnan, David Rampe, Wei Zheng, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers (ISBN: ) from Amazon's Book Store. Everyday low prices and free delivery on eligible orders. Drug targets: ligand and voltage gated ion channels Article (PDF Available) in International Journal of Basic & Clinical Pharmacology 6(2) January with 5, Reads How we measure 'reads'.
Voltage-gated ion channels that are selectively permeable to each of the major physiological ions—Na+, K+, Ca2+, and Cl-—have now been discovered (Figure A-D).
Indeed, many different genes have been discovered for each type of voltage-gated ion channel. For example, 10 human Na+ channel genes have been identified. This finding was unexpected because Na+ channels from many. Assay technology and target-driven drug discovery.
Target-driven drug discovery is still in its infancy for VGSCs, similar to other voltage-gated ion channels. The technical issues that have inhibited it are: (1) stable expression of VGSCs and (2) robust high-throughput assays.
Ion channels are important drug targets because they play a crucial role in controlling a very wide spectrum of physiological processes (Hille, ), and because their dysfunction can lead to pathophysiology (Ashcroft, ).Given the strong historical precedent that exists for discovering and commercializing successful drugs that modulate the activity of voltage-gated sodium, calcium, or.
Voltage-gated sodium (Nav) channels represent an important class of drug target for pain and many other pathology conditions. Despite the recent advances in channelopathies and structure-function studies, the discovery of Nav channel therapeutics is still facing a major challenge from the limitation of assay technologies.
This chapter will focus on advancement and challenge of Nav drug. The sodium leak channel, non-selective (provisionally assigned as Na Vi ) is structurally related to the voltage-gated sodium channel family (Na v – Na v ), but is voltage-insensitive and displays distinctive ion selectivity and pharmacological properties.
Introduction: on ion channels / Murali Gopalakrishnan, David Rampe, David Triggle, Wei Zheng --The voltage-gated ion channel superfamily / William A. Catterall --State-dependent drug interactions with ion channels / Stefan I. McDonough, Bruce P.
Bean --Assay technologies: techniques available for quantifying drug-channel interactions / Derek. Voltage-gated sodium channels (Nav) control the initiation and propagation of action potential, and thus mediate a broad spectrum of physiological processes, including central and peripheral nervous systems’ function, skeletal muscle contraction, and heart rhythm.
Recent advances in elucidating the molecular basis of channelopathies implicating Nav channels are the most appealing druggable.
Request PDF | Voltage-Gated Ion Channels as Drug Targets, Volume 29 | Structure of the Kv ChannelPharmacological Significance of the Kv ChannelKnown Drugs with Activity on. voltage-gated ion channels; nuclear hormone receptors; structural proteins such as tubulin; membrane transport proteins; nucleic acids; Drug target identification.
Identifying the biological origin of a disease, and the potential targets for intervention, is the first step in the discovery of a medicine using the reverse pharmacology approach. Voltage-gated Sodium Channels 7. Voltage-gated Calcium Channels 9. Voltage-gated Potassium Channels Inwardly Rectifying Potassium Channels Common Aspects of Ion Channel Structure and Function Conclusions 3 State-dependent Drug Interactions with Ion Channels 19 Stefan I.
McDonough and Bruce P. Bean. Introduction. After protein kinases and G-protein coupled receptors, voltage-gated-like ion channels (VGICs) constitute the third largest group of signaling molecules in the human genome 78 members, potassium channels make up about half of this extended gene superfamily and can be divided into four structural types based on their mode of activation and the number of their transmembrane.
Title: Voltage-Gated Ion Channels, New Targets in Anti-Cancer Research VOLUME: 2 ISSUE: 3 Author(s):Le Guennec Jean-Yves, Ouadid-Ahidouch Halima, Soriani Olivier, Besson Pierre, Ahidouch Ahmed and Vandier Christophe Affiliation:Inserm E Nutrition Croissance Cancer, Universite François-Rabelais de Tours, Faculte de Medecine, 10 Bd Tonnelle, Tours, France.
Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology.
The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic. In this chapter we introduce both voltage-gated and ligand-gated ion channels that are abundantly expressed within the central nervous system and the peripheral nervous system.
Here, we discuss their roles in neurological disorders and introduce some common clinically used drugs that target ion channels as a means of treatment.
This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment.Pris: kr.
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Ed. by David J. Triggle et al. Wiley-VCH pages $ Hardcover.